fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. A further embodiment of the invention includes a method for stabilizing a hydroquinone composition (with about 1% to about 12% hydroquinone, preferably about 2% to about 10%, more preferably about 2% to about 8%, and most preferably about 3% to about 4%) with a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, by adding a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate. HlRMo0WB:NnVCnE4(i0 (1* )@NzHR!>i;8XaXnsO0LNT0l$B%"NAb0I9V *6/-\vn0W"fKF:AAgl:psRZ?k`&eB IUQ0ET;W#vL=@XwRG{-LHlTz]^s%OB(GF 11'I Conversion factors (at 25C and normal atmospheric pressure) 1 ppm = 4.5 mg/m 3 1 mg/m 3 = 0.222 ppm Table 1. Have an order or account question, find answers in our Online Support articles. Stir until uniform. It is a major component in most black and white photographic developers for film and paper where, with the compound metol, it reduces silver halides to elemental silver. Hydroquinone IS a white crystalline substance when pure and is highly soluble in water. Add the hydroquinone to the water. Methylaminophenol, used in photography, is produced in this way:[8]. uuid:a150f3fd-7f22-4439-aa26-6f445f4017e5 endstream endobj 277 0 obj <>stream You take the cream, put it in a container, take the powder measurement and add it. The solubility was increased by addition of ethanol, reached a maximum . Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. A common route involves hydroxylation of phenol. 43, 13111316 (2007), J. Qing-Zhu, M. Pei-Sheng, Z. Huan, X. Shu-Qian, W. Qiang, Q. Yan, Fluid Phase Equilib. Read our Privacy Notice. The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Res. Hydroquinone is highly susceptible to ring substitution by Friedel-Crafts reactions such as alkylation. nQt}MA0alSx k&^>0|>_',G! ~lgM~Gc{1S_1Q/_/v">S 9 Phase A is added to the tank, which is held at a temperature of from about 70 to about 75 C, and in which a CO. Hydroquinone is soluble in alcohol solvents such as ethanol and methanol [17]. Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. Availability. The aquatic toxicity of hydroquinone to fresh water fish, Daphnia, and algae was between 0.050- . This range of pH has been preferred for hydroquinone compositions, because it has been believed that the hydroquinone is less likely to excessively discolor under acid conditions. endstream endobj 1 0 obj <> endobj 2 0 obj <> endobj 12 0 obj <>stream Do not put this product in the microwave. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. At 40C, 4% hydroquinone compositions are more likely to excessively discolor and magnesium ascorbyl phosphate helps to stabilize the color, by preventing the brownish black discoloration and maintaining an amber color. An improvement in the color stability of the 4% hydroquinone compositions is seen at and above 2.0% magnesium ascorbyl phosphate in the 6-7 pH range. Hydroquinone is extensively used as a photographic developer, an antioxidant, and a stabilizing agent for readily oxidizable polymers. Heat Mass Transf. Calorim. These can be burning, redness, sensitization and irritation in some patients. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. 0000002221 00000 n All Rights Reserved, View All Eastman Hydroquinone USP Articles. Hydroquinone Safety Data Sheet according to Federal Register / Vol. Please sign in to view account pricing and product availability. SAS Anti-ox booster 1% 0.3g. J. Preparation, optimization and in vivo. On this Wikipedia the language links are at the top of the page across from the article title. Solubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol Features & Benefits Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMO Extremely low vapor pressure USP Grade European Pharma Grade Drug master file available upon request Applications The reservoir opens through a muscle-controlled valve onto a thick-walled reaction chamber. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C 6 H 6 O 2; molecular weight is 110.0. 0000002585 00000 n Pigmentation disorders can take a variety of forms like hyperpigmentation and hypopigmentation, such as melasma (dark patches experienced in pregnancy), liver spots (which often develop with age), as a side effect of birth control pills, and as a persistent result of acne, bums, bites and other skin injuries, and vitiligo. Cookie Notice stearic, palmitic, arachidic acids, Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. Ferulic acid 0.5% 0.15g. https://doi.org/10.1007/s10765-020-02750-4. New experimental data are provided for the solubility of resorcinol in water and salicylic acid, resorcinol, hydroquinone in 1-octanol. Eng. [23] This conclusion was reached based on the extent of absorption in humans and the incidence of neoplasms in rats in several studies where adult rats were found to have increased rates of tumours, including thyroid follicular cell hyperplasias, anisokaryosis (variation in nuclei sizes), mononuclear cell leukemia, hepatocellular adenomas and renal tubule cell adenomas. The obtained results show that the solubility of benzoic acid in water is greater than that of salicylic acid, but in the case of the two isomers of dihydroxybenzene, the solubility of resorcinol is approximately 100 times that of hydroquinone. vitamin C; Salts thereof, Medicinal preparations containing active ingredients not provided for in groups A61K31/00-A61K41/00, Mixtures of active ingredients without chemical characterisation, e.g. It is highly soluble in water (70 g/litre at 25 C) and the log n-octanol/water partition coefficient is 0.59. Human exposure to hydroquinone can occur by dietary, occupational, and environmental sources. ADS endstream endobj 382 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /BCGJCE+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /XHeight 0 /FontFile2 389 0 R >> endobj 383 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 181 /Widths [ 250 0 0 0 0 0 0 278 333 333 500 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 333 333 0 570 0 0 0 722 667 722 722 667 611 778 778 389 500 778 667 944 722 778 611 778 722 556 667 722 722 1000 722 722 0 333 0 333 0 0 0 500 556 444 556 444 333 500 556 278 333 556 278 833 556 500 556 556 444 389 333 556 500 722 500 500 444 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 576 ] /Encoding /WinAnsiEncoding /BaseFont /BCGJCE+TimesNewRoman,Bold /FontDescriptor 382 0 R >> endobj 384 0 obj << /Type /FontDescriptor /Ascent 929 /CapHeight 0 /Descent -249 /Flags 32 /FontBBox [ -184 -249 1037 929 ] /FontName /BCGKAB+ImprintMT-Shadow /ItalicAngle 0 /StemV 0 /FontFile2 390 0 R >> endobj 385 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 122 /Widths [ 250 0 0 0 0 0 0 0 323 323 0 0 0 375 240 0 510 427 510 510 0 510 0 510 510 510 0 0 0 0 0 0 0 729 0 729 0 698 0 0 854 0 0 0 0 927 802 813 0 0 0 604 0 0 0 0 802 0 0 0 0 0 0 0 0 448 552 0 552 448 0 0 573 271 0 0 271 875 573 500 0 552 375 0 323 573 0 0 0 500 448 ] /Encoding /WinAnsiEncoding /BaseFont /BCGKAB+ImprintMT-Shadow /FontDescriptor 384 0 R >> endobj 386 0 obj << /N 3 /Alternate /DeviceRGB /Length 2575 /Filter /FlateDecode >> stream This invention relates to methods and compositions for the treatment of pigmentation disorders, including hyperpigmentation and vitiligo. uuid:3780f5dc-b322-4e29-9b1d-4c4d10b1e282 &"oq YcbX.=a*t R@ A preferred embodiment utilizes encapsulation. AzA inhibits tyrosinase. All information collection is solely used to support ChemPoint customers service communications. Since the neutral pH of the hydroquinone composition with sodium metabisulfite and magnesium ascorbyl phosphate is preferably from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, the pH is acceptable for also including retinoids in the composition. Table II shows that at 5C, 4% hydroquinone compositions maintain their white or light straw color with the addition of at least about 0.5% magnesium ascorbyl phosphate at the low pH ranges (from about 3.50 to about 5.50) and when about 1.0 to about 2.0% magnesium ascorbyl phosphate is used in the pH range of about 7.0. Why we like it: This affordable cream contains 2 percent hydroquinone, sunscreen, and costs around five dollars. Thank you for your inquiry and interest in ChemPoint. Continue rinsing.IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.Avoid release to the environment.WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. Hi, let us know if you have any questions as you visit our website. x- [ 0}y)7ta>jT7@t`q2&6ZL?_yxg)zLU*uSkSeO4?c. R -25 S>Vd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L` "AYA+Cb(R, *T2B- antiphlogistics and cardiaca, Cosmetics or similar toilet preparations characterised by the composition, Cosmetics or similar toilet preparations characterised by the composition containing inorganic ingredients, Sulfur; Selenium; Tellurium; Compounds thereof, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen, . [27] Several such agents are already available or under research,[28] including azelaic acid,[29] kojic acid, retinoids, cysteamine,[30] topical steroids, glycolic acid, and other substances. In 1-octanol, the decreasing order of the solubility of these compounds is as follows: resorcinol>benzoic acid>salicylic acid>hydroquinone. However, hydroquinone discolors at the pH range of 7.0 to 8.5. application/pdf isosorbide, Ascorbic acid, i.e. Can be destroyed by oxidizing it with an oxidizing mixture. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. PubMedGoogle Scholar. HyTSwoc [5laQIBHADED2mtFOE.c}088GNg9w '0 Jb Hydroquinone (C6H4(OH)2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. English, J.C. and Deisinger, P.J. This compound is gathered from the beaver's castor sacs.[35]. and our The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. Eng. I can only tell you how to mix the powder solution to the liquid solvent. 2023 Springer Nature Switzerland AG. Hydroquinone[1] Idrochinone Quinol 1,4-Dihydroxybenzene p-dihydroxybenzene p-hydroxyphenol 1,4-Hydroxy benzene Identifiers CAS Number 123-31-9 Y 3D model (JSmol) Interactive image Beilstein Reference 605970 ChEBI CHEBI:17594 Y ChEMBL ChEMBL537 Y ChemSpider 764 Y DrugBank DB09526 ECHA InfoCard 100.004.199 EC Number 204-617-8 Gmelin Reference 2742 The experimental solubility data was well-correlated with the data, calculated by . HMkA+"c>jZ^ho=81NW;]Ib;+i#iFArHpz). `9F6~qg3]0,#!V9Q> p=|h| GHS P Statement: Wear protective gloves/protective clothing/eye protection/face protection.Call a POISON CENTER or doctor/physician if you feel unwell.IF ON SKIN: Gently wash with plenty of soap and water.IF IN EYES: Rinse cautiously with water for several minutes. Boucif Belhachemi. Get medical attention. Hydroquinone occurs in the environment as a result of anthropogenic processes, as well as in natural products from plants and animals. Other antioxidants, for example cationic salts of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, and sodium ascorbyl phosphate, have not been utilized in combination with hydroquinone in view of the acidic pH, generally from about 3.4 to about 3.5, and the recommended pH range for magnesium ascorbyl phosphate is about 7.0 to 8.5. Eastman Hydroquinone, USP Grade is for skin-lightening products to address hyperpigmentation. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Re: How to dissolve Hydroquinone to make 4 oz. 2005 Wiley-VCH, Weinheim. Free format text: 58 / Monday, March 26, 2012 / Rules and Regulations 10/31/2017 EN (English US) 6/8 12.3. Toxicol. Chem. So, does anybody know of another solvent I could use that has a higher . However, the oil-soluble TBHQ is more hydrophobic with a distinctly increased log P value compared to HQ. NR 1L~tyj|ZZ3]jFlszH#bd]="nVj =rBF-=Y?Pe 3(\[3;wR-+7Fn ~pSQ(Rpiw^zYr''t@\vobE]u'C}io0q;^k5C@|zZNNA>,XOrztV;qO*w:MC$OI\_$Io 'v [ 114, 175188 (1996), I. Hahnenkamp, G. Graubner, J. Gmehling, Int. Thanks to the added vitamin E, it leaves your skin feeling smooth and soft, too. Correspondence to It is understood that while the invention has been described in conjunction with the detailed description thereof, that the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. If you are already a ChemPoint customer then sign up for access to our online ordering website. The Beaver: Its Life and Impact. C6H4O2) is formed. [21] The FDA officially banned hydroquinone in 2020 as part of a larger reform of the over-the-counter drug review process. Therefore, the solubility values of hydroquinone in different solvents are required; however, the data availability in the literature is poor.3-7 In this work, the solubility data of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid from 276.65 K to 345.10 K under atmospheric pressure were . I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. Other properties of hydroquinone are given in Table 1. V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= At 40C, 4% hydroquinone compositions have the same color stability with slightly more sodium metabisulfite, at least about 0.01% at about 3.5 to about 4.0 pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at least about 0.10% sodium metabisulfite at about 6.5 to about 7.0 pH. Found. This is a prescription-only ingredient in some countries, including the member states of the European Union under Directives 76/768/EEC:1976. 0000008514 00000 n Data 53, 12781282 (2008), A. Thermodyn. Rev. The composition is preferably formulated in separate phases as designated below. As utilized herein, the inhibition of the retinoid oxidation should be sufficient to prohibit browning of the composition for its shelf life, preferably greater than about six months, more preferably greater than about twelve months, and most preferably greater than about eighteen months. We have found that a cream containing 5% of hydroquinone and 0.05 % of laevo-ascorbic acid remains white, and the emulsion remains unbroken after many months of storage, The laevo-ascorbic or cevitamic acid is pr'eferably employed in the free condition; but if desired, the salts, and especially the water-soluble salts thereof, may be employed . Hydroquinone is a major benzene metabolite, which is a well-known haematotoxic and carcinogenic agent associated with malignancy in occupational environments. protecting the retinoids in a protective system; mixing the hydroquinone, and the protected retinoids; and. It does not have the same predisposition to cause dermatitis as metol does. It would be desirable to combine the pigmentation disorder treatment with this skin benefit ingredient in one composition. Formula of hydroquinone is . Anal. This page was last modified on 19 June 2019, at 20:05. An acceptable carrier also possesses suitable aesthetic and cosmetic qualities and may include emollients, conditioners and the like. Hydroquinone is an aromatic organic compound which is currently used in two main sectors: . 76/768/EEC:1976 Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products: Organic Chemistry, Solomon and Fryhle, 10th edition, Wiley Publishing, 2010. Cite this article. Have an order or account question? Hydroquinone, 99.5%, Thermo Scientific Chemicals 5g, Glass Bottle Quantity: 5g 50g 250g 1kg 5kg Packaging: Glass Bottle Plastic Drum Plastic bottle Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. However, a problem with a formulation containing both retinoids and hydroquinone has been their incompatible pH ranges. A method of stabilizing a hydroquinone composition, comprising hydroquinone and one or more protected retinoids, comprising: maintaining pH of the composition at about 5.5 to about 8.0. Hydroquinone (C 6 H 4 (OH) 2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. Classical photo shops . How to dissolve Hydroquinone to make 4 oz. Other adverse effects 0000005757 00000 n It has a white-solid appearance. Then add it to the ingredients. Water Solubility 73000 mg/L at 25C 2.6B pH pKa 4.0 - 4.7 pK1 = 9.9 2.12 Oxidation:Reduction Potential +286 mV at 25C and pH 7 ENVIRONMENTAL FATE/BIODEGRADATION By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. COMMON BRAND NAME (S): Aclaro, Aclaro PD, Alera, Alphaquin HP, Alustra, Claripel, Complex B . Then take the water and put the measurement into the microwave until boiled. N')].uJr If youd like my help or recipes for this bleaching cream please contact me on Instagram @kaylinell and @kay.linell or Facebook at kay linell. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), are beneficial for improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. The Boiling Point of hydroquinone is 287C Also, the Melting Point of hydroquinone is 172C. HYPERPIGMENTARY STAIN ELIMINATING CREAM FOR FACE SKIN AND ITS USE. The Molecular Weight is 110.11 g/mol. Hydroquinone is sold by chemical suppliers. Canon Google Scholar, W. J. Weber Jr, Y.-P. Chin, C. P. Rice, Water Res. Other solubilities: soluble in alcohol and ether,slightly soluble in benzene,readily soluble in ethanol,acetone and methanol, Needle-like Crystals or Crystalline Powder. vz >I d50dwp?i4,H3. Belhachemi, B., Makhlouf, H. & Belhachemi, M.H. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. [Na+].OC(=O)CC(O)(CC([O-])=O)C(O)=O.OC(=O)CC(O)(CC([O-])=O)C(O)=O, SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS, Preparations for care of the skin for chemically bleaching or whitening the skin, PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES, Medicinal preparations containing organic active ingredients, Acids; Anhydrides, halides or salts thereof, e.g. 4]DYR@'c Hydroquinone Revision Date 24-Dec-2021 General Advice If symptoms persist, call a physician. Solute (1 g) Water Boiling Water Alcohol Chloroform Ether Other Acenocoumarol 67,000 280 130 1800 Acetaminophen 20 10 1 N sodium hydroxide, 15 Acetohexamide 230 210 Acetylcysteine 5 4 Acetyldigitoxin 6100 62.5 12 >10,000 Ammonium Alum 7 0.5 Aluminum Chloride 0.9 4 Aluminum Sulfate 1 Amantadine Hydrochloride 2.5 5.1 18 polyethylene glycol 400, 70 Some hydroquinone compositions include antioxidants, such as ascorbyl palmitate. 250, 165172 (2006), F. L. Mota, A. J. Queimada, A. E. Andreatta, S. P. Pinho, E. A. Macedo, Fluid Phase Equilib. 552591, Z. Esina, M. Korchuganova, Theor. Phillip M. Hudnall "Hydroquinone" in Ullmann's Encyclopedia of Industrial Chemistry 2002, Wiley-VCH, Weinheim. n3kGz=[==B0FX'+tG,}/Hh8mW2p[AiAN#8$X?AKHI{!7. It is also used to prepare 2% bleaching creams and certain intermediates for the synthesis of dyes, and it has some activity as an antitumoragent. Consistent with a condensation reaction, water was determined to be the primary byproduct. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Eng. You take the cream, put it in a container, take the powder measurement and add it. This study was funded by Ministre de l'Enseignement Suprieur et de la Recherche Scientifique. Although about 0.01% sodium metabisulfite without magnesium ascorbyl phosphate may not color stabilize an about 4% hydroquinone composition, and about 0.5% magnesium ascorbyl phosphate without sodium metabisulfite may not either, the combination of sodium metabisulfite and magnesium ascorbyl phosphate in these percentages is effective to stabilize the color of the about 1% to about 12%, about 2% to about 10%, preferably about 2% to about 8% and more preferably about 3% to about 4% and most preferably 4% hydroquinone composition. [24], Numerous studies have revealed that hydroquinone, if taken orally, can cause exogenous ochronosis, a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ingredient are administered topically. uv curable cellulose estersuv curable cellulose esters . . Diamines, useful in the rubber industry as antiozone agents, are similarly produced from aniline: Hydroquinone has a variety of uses principally associated with its action as a reducing agent that is soluble in water. Hydroquinone, like phenols are very weak acids and can be deprotonated. The combined nearly ideal binary solvent (NIBS)-Redlich-Kister equation is . Thus, merely adding one retinoid to a hydroquinone composition would result in instability and/or discoloration, and adding hydroquinone to a retinoid product would have a similar result. While patients suffer from pigmentation disorders, they may also suffer from other skin disorders and signs of aging, including but not limited to rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. The Campaign for Safe Cosmetics has also highlighted concerns. Chim. I would like to add retinol and kojic acid to it as well. Substituted derivatives of this parent compound are also referred to as hydroquinones. One of these, 4-butylresorcinol, has been proven to be more effective at treating melanin-related skin disorders by a wide margin, as well as safe enough to be made available over the counter. Stir until uniform. Color stability improvement is evident at all levels. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. 230, 176183 (2005), A. Apelblat, E. Manzurola, N. A. Balal, J. Chem. Adobe Acrobat 10.1.6 Paper Capture Plug-in 0000053439 00000 n 12.4. As a polymerisation inhibitor, exploiting its antioxidant properties, hydroquinone prevents polymerization of acrylic acid, methyl methacrylate, cyanoacrylate, and other monomers that are susceptible to radical-initiated polymerization. Johnson & Johnson Consumer Products, Inc. Johnson & Johnson Consumer Companies, Inc. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN, Color Stability of 4% HQ Compositions with varying pH and % Sodium Metabisulfite at 5C and 40C, Color Stability of 4% HQ Compositions with varying pH and % Magnesium Ascorbyl Phosphate at 5C and 40C, Polyacrylamide (and) C 13-14 isoparaffin (and) laureth-7, Water, Soybean (Glycine Soja) Oil, Carnauba (Copemicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Water, Soybean (Glycine Soja) Oil, Carnauba (Copernicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Compositions for the treatment of pigmentation disorders and methods for their manufacture, Stabilization composition including hydroquinone or derivative thereof, Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof, Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent, Depigmenting composition for the skin, use of a depigmenting composition for the skin, cosmetic use of the same and method for non-therapeutic cosmetic treatment, Cosmetic designs and products using intronic RNA, Holistic composition and method for reducing skin pigmentation, Topical compositions and methods of manufacturing them in specifically treated steel vessels, System for improved percutaneous absorption of skin benefiting agents, Discontinuous surface coating for particles, Method of treating skin requiring chemical peel procedure, Method of treating skin needing hyaluronic acid treatment, Method of treating skin having incision from surgical procedures, Method of treating skin requiring hair removal procedure, Method of treating skin requiring Intense Pulse Light (IPL) procedure, Method of treating skin subject to or affected by aesthetic surgical procedures, Method of treating skin needing ablative treatment, Method of treating skin requiring radiofrequency procedure, Method of treating skin requiring non-ablative procedure, Method of treating skin requiring fractional resurfacing treatment, Method of treating skin needing botulinum toxin type a treatment, Method of treating skin requiring microdermabrasion, Method of treating skin needing collagen treatment, Method of treating skin requiring skin cancer treatment, Methods of treating skin to enhance therapeutic treatment thereof, Ras mutation and compositions and methods related thereto, Compositions, kits and regimens for the treatment of skin, especially dcolletage, Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions.
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